Back to Search
Start Over
Topical application of two condensed tannins from the root of Rosa multiflora Thunberg for the treatment of atopic dermatitis (AD) in NC/Nga mice
- Source :
- Phytotherapy research : PTR. 25(10)
- Publication Year :
- 2010
-
Abstract
- Recently, the isolation of several condensed tannins from the roots of Rosa multiflora Thunberg, a traditional herbal therapy in oriental medicine for rheumatoid arthritis and scabies, was described. Two of the major condensed tannins - procyanidin B-3 (ProB3) and ent-guibourtinidol-(4β → 6)-catechin (RM-1) - were then applied topically to atopic dermatitis-like skin lesions on NC/Nga mice in order to assess their immunomodulatory properties. Both ProB3 and RM-1 significantly reduced the serum levels of eosinophils, IgE and certain Th2 cytokines (IL-4, 5 and 13) (p 0.05 or 0.01). Additionally, ProB3 and RM-1 significantly reduced both the mRNA and protein expression of COX-2 and iNOS in mouse skin tissues (p 0.01). Such results strongly suggest that ProB3 and RM-1 may be useful in the treatment allergic skin conditions, most notably atopic dermatitis.
- Subjects :
- Plant Extracts
Administration, Topical
Nitric Oxide Synthase Type II
Mice, Inbred Strains
Immunoglobulin E
Rosa
Plant Roots
Catechin
Dermatitis, Atopic
Eosinophils
Mice
Th2 Cells
Animals
Biflavonoids
Cytokines
Immunologic Factors
Cyclooxygenase Inhibitors
Female
Proanthocyanidins
RNA, Messenger
Phytotherapy
Skin
Subjects
Details
- ISSN :
- 10991573
- Volume :
- 25
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Phytotherapy research : PTR
- Accession number :
- edsair.pmid..........d47ca4169b79e6f577d7a7896daf3d24