In Vitro and In Vivo Inhibition of the

Authors :: Samantha, Ottavi
Sarah M, Scarry
John, Mosior
Yan, Ling
Julia, Roberts
Amrita, Singh
David, Zhang
Laurent, Goullieux
Christine, Roubert
Eric, Bacqué
H Rachel, Lagiakos
Jeremie, Vendome
Francesca, Moraca
Kelin, Li
Andrew J, Perkowski
Remya, Ramesh
Matthew M, Bowler
William, Tracy
Victoria A, Feher
James C, Sacchettini
Ben S, Gold
Carl F, Nathan
Jeffrey, Aubé
Source :: Journal of medicinal chemistry. 65(3)
Publication Year :: 2022
Abstract: A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in

Subjects :: Kinetics
Structure-Activity Relationship
Binding Sites
Bacterial Proteins
Molecular Conformation
Transferases (Other Substituted Phosphate Groups)
Urea
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Molecular Dynamics Simulation
Crystallography, X-Ray
Guanidine

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