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Interest of PS100 assay when (99m)Tc sestamibi scintigraphy failed to identify lymph node metastases of melanoma
- Source :
- European journal of dermatology : EJD. 11(5)
- Publication Year :
- 2001
-
Abstract
- The study evaluated the contribution of serum PS100 assay to the detection of lymph node metastases during the follow-up of patients previously treated for a malignant melanoma, in addition to (99m)Tc sestamibi (MIBI) scintigraphy and investigation for gene MDR1, in order to detect chemoresistance phenomena. The study included 37 patients with a clinically questionable lymph node around basin lymphatic areas of the previously surgically-treated malignant melanoma. The sensitivity and specificity of PS100 assay were 91% and 86.5%, respectively. The sensitivity and specificity of MIBI scintigraphy were 95% and 85%, respectively. Overexpression of gene MDR1 was observed in six cases. In the event of negative scintigraphic findings, the concomitant analysis of PS100 levels and the scintigraphic result enabled the metastatic MDR+ patients to be distinguished from the non-metastatic patients. PS100 assay may therefore be proposed for the follow-up of malignant melanoma.
- Subjects :
- Diagnosis, Differential
Gene Expression Regulation, Neoplastic
Technetium Tc 99m Sestamibi
Skin Neoplasms
Reverse Transcriptase Polymerase Chain Reaction
Lymphatic Metastasis
S100 Proteins
Humans
ATP Binding Cassette Transporter, Subfamily B, Member 1
RNA, Messenger
Radionuclide Imaging
Melanoma
Sensitivity and Specificity
Subjects
Details
- ISSN :
- 11671122
- Volume :
- 11
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- European journal of dermatology : EJD
- Accession number :
- edsair.pmid..........d08a8aa1d362c4d4a21de9302b0a44ca