Prevention of High-Fat Diet-Induced Hypercholesterolemia by

C57BL/6N mice were fed a low-fat diet or a high-fat diet and gavage with Fn041 andBoth Fn041 and LGG prevented the occurrence of hypercholesterolemia, liver and testicular fat accumulation. In addition, a high-fat diet causes intestinal dysbiosis and mucosal barrier damage, which is associated with hypercholesterolemia. Fn041 prevented the high-fat diet-induced reduction in alpha diversity of intestinal microbiota and intestinal mucosal barrier damage. Fn041 treatment significantly increased fecal total cholesterol and total bile acids.Fn041 prevented hypercholesterolemia by enhancing cholesterol excretion and mucosal barrier function.