Back to Search
Start Over
Disruption of 5-HT
- Source :
- Neuropharmacology. 125
- Publication Year :
- 2017
-
Abstract
- Antidepressants remain one of the first line treatments prescribed to neuropathic pain patients despite their limited efficacy and/or their numerous side effects. More and more, pharmacotherapy for neuropathic pain has evolved towards the use of therapeutic combinations. The goal of the present study was to assess the efficacy of the combination of antidepressants - selective serotonin reuptake inhibitors and serotonin-noradrenaline reuptake inhibitors-with a peptide (TAT-2ASCV) able to disrupt the interaction between serotonin type 2A (5-HT
- Subjects :
- Male
PDZ Domains
Peripheral Nervous System Diseases
Analgesics, Non-Narcotic
Duloxetine Hydrochloride
Receptors, GABA-A
Sciatic Nerve
Rats, Sprague-Dawley
Disease Models, Animal
Hyperalgesia
Touch
Fluoxetine
Clomipramine
Animals
Neuralgia
Receptor, Serotonin, 5-HT2A
GABA-A Receptor Agonists
Serotonin and Noradrenaline Reuptake Inhibitors
Serotonin 5-HT2 Receptor Agonists
Selective Serotonin Reuptake Inhibitors
Subjects
Details
- ISSN :
- 18737064
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Neuropharmacology
- Accession number :
- edsair.pmid..........cf1f3a829f924dc235b2de383a15b2fa