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Disruption of 5-HT

Authors :
Anne-Sophie, Wattiez
Amandine, Dupuis
Anne-Marie, Privat
Maryse, Chalus
Eric, Chapuy
Youssef, Aissouni
Alain, Eschalier
Christine, Courteix
Source :
Neuropharmacology. 125
Publication Year :
2017

Abstract

Antidepressants remain one of the first line treatments prescribed to neuropathic pain patients despite their limited efficacy and/or their numerous side effects. More and more, pharmacotherapy for neuropathic pain has evolved towards the use of therapeutic combinations. The goal of the present study was to assess the efficacy of the combination of antidepressants - selective serotonin reuptake inhibitors and serotonin-noradrenaline reuptake inhibitors-with a peptide (TAT-2ASCV) able to disrupt the interaction between serotonin type 2A (5-HT

Details

ISSN :
18737064
Volume :
125
Database :
OpenAIRE
Journal :
Neuropharmacology
Accession number :
edsair.pmid..........cf1f3a829f924dc235b2de383a15b2fa