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Adverse effects of methylene blue in peripheral neurons: An
Adverse effects of methylene blue in peripheral neurons: An
- Source :
- Molecular pain. 18
- Publication Year :
- 2022
-
Abstract
- Methylene blue (MB) is an effective treatment for methemoglobinemia, ifosfamide-induced encephalopathy, cyanide poisoning, and refractory vasoplegia. However, clinical case reports and preclinical studies indicate potentially neurotoxic activity of MB at certain concentrations. The exact mechanisms of MB neurotoxicity are not known, and while the effects of MB on neuronal tissue from different brain regions and myenteric ganglia have been examined, its effects on primary afferent neurons from dorsal root ganglia (DRG) have not been studied. Mouse DRG were exposed to MB (0.3-10 μM)
Details
- ISSN :
- 17448069
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Molecular pain
- Accession number :
- edsair.pmid..........cdde8811ee09494fc3fa2e16b6942904