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Adverse effects of methylene blue in peripheral neurons: An

Adverse effects of methylene blue in peripheral neurons: An

Authors :
Megan L, Uhelski
Malcolm E, Johns
Alec, Horrmann
Sadiq, Mohamed
Ayesha, Sohail
Iryna A, Khasabova
Donald A, Simone
Ratan K, Banik
Source :
Molecular pain. 18
Publication Year :
2022

Abstract

Methylene blue (MB) is an effective treatment for methemoglobinemia, ifosfamide-induced encephalopathy, cyanide poisoning, and refractory vasoplegia. However, clinical case reports and preclinical studies indicate potentially neurotoxic activity of MB at certain concentrations. The exact mechanisms of MB neurotoxicity are not known, and while the effects of MB on neuronal tissue from different brain regions and myenteric ganglia have been examined, its effects on primary afferent neurons from dorsal root ganglia (DRG) have not been studied. Mouse DRG were exposed to MB (0.3-10 μM)

Details

ISSN :
17448069
Volume :
18
Database :
OpenAIRE
Journal :
Molecular pain
Accession number :
edsair.pmid..........cdde8811ee09494fc3fa2e16b6942904