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[Inhibition of the protein PCSK9 is a promising target in the prevention of cardiovascular disease]
- Source :
- Ugeskrift for laeger. 177(11)
- Publication Year :
- 2015
-
Abstract
- Recent research in genetics has revealed that PCSK9 - which codes for proprotein convertase subtilisin/kexin type 9 (PCSK9) - plays a major role in cholesterol regulatory pathways. Normal genetic variations in PCSK9 have a great impact on low-density lipoprotein cholesterol levels and hence the risk of cardio-vascular disease. This has led to huge efforts in inhibiting PCSK9. Recent clinical phase II trials with monoclonal antibodies against PCSK9 have shown great results for lowering low-density lipoprotein cholesterol levels making the inhibition of PCSK9 a promising target in the prevention of cardiovascular disease.
Details
- ISSN :
- 16036824
- Volume :
- 177
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Ugeskrift for laeger
- Accession number :
- edsair.pmid..........cd59791c119003e726be6fc3a35b07bc