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Neuronal and Peripheral Pentraxins Modify Glutamate Release and may Interact in Blood-Brain Barrier Failure
- Source :
- Cerebral cortex (New York, N.Y. : 1991). 27(6)
- Publication Year :
- 2016
-
Abstract
- Neuronal pentraxin 1 (NPTX1) has been implicated in Alzheimer's disease, being present in and around dystrophic neurons in plaques, affecting glutamatergic transmission postsynaptically and mediating effects of amyloidβ. Here, we confirm the presence of NPTX1 around plaques in postmortem Alzheimer's disease brain and report that acutely applied human NPTX1 increases paired-pulse ratio at mouse CA3-CA1 hippocampal synapses, indicating a decrease in glutamate release. In contrast, chronic exposure to NPTX1, NPTX2, or NPTX receptor decreases paired-pulse ratio, mimicking some of the earliest changes in mice expressing familial Alzheimer's disease genes. The peripheral pentraxin, serum amyloid P component (SAP), causes similar synaptic effects to NPTX1. The presence of SAP on amyloid plaques in Alzheimer's disease confirms that it can enter the brain. We show that SAP and neuronal pentraxins can interact and that SAP can enter the brain if the blood-brain barrier is compromised, suggesting that peripheral pentraxins could affect central synaptic transmission via this interaction, especially in the event of blood-brain barrier breakdown.
- Subjects :
- Aged, 80 and over
Lipopolysaccharides
Male
Neurons
Glutamic Acid
Mice, Transgenic
Nerve Tissue Proteins
Middle Aged
Hippocampus
GABA Antagonists
Mice, Inbred C57BL
Pyridazines
Mice
Serum Amyloid P-Component
C-Reactive Protein
HEK293 Cells
Animals, Newborn
Alzheimer Disease
Blood-Brain Barrier
Synapses
Animals
Humans
Female
Evoked Potentials
Subjects
Details
- ISSN :
- 14602199
- Volume :
- 27
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Accession number :
- edsair.pmid..........cd54e0d0a4c6e43f4f610bf1ee221a9a