A note on the preparation of particulate material for an electron microscopic study

Modifications of two rapid and satisfactory procedures of purification of minute biological particulate material for electron microscopic observations were described. These modifications eliminate the alterations of the investigated particles and the possibility of their artificial disintegration. In addition, these procedures preserve the grouping of the particles as compared with the original suspensions. The dialysis is made directly on the grids coated with the supporting formvar membrane. In the second procedure the filtration of the soluble components of the material into the agar is combined with the transfer of the particles on the membrane covered grids.