CD4

Authors :: David, Gate
Emma, Tapp
Olivia, Leventhal
Marian, Shahid
Tim J, Nonninger
Andrew C, Yang
Katharina, Strempfl
Michael S, Unger
Tobias, Fehlmann
Hamilton, Oh
Divya, Channappa
Victor W, Henderson
Andreas, Keller
Ludwig, Aigner
Douglas R, Galasko
Mark M, Davis
Kathleen L, Poston
Tony, Wyss-Coray
Source :: Science (New York, N.Y.). 374(6569)
Publication Year :: 2021
Abstract: Recent studies indicate that the adaptive immune system plays a role in Lewy body dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is unknown. Here, we observed T cells adjacent to Lewy bodies and dopaminergic neurons in postmortem LBD brains. Single-cell RNA sequencing of cerebrospinal fluid (CSF) identified up-regulated expression of

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