[Incidence of hydatidiform mole and aging of mothers (author's transl)]

The incidence of hydatidiform mole, found in Fukushima Prefecture from 1975 to 1979 (5 years), in all pregnant women was statistically studied according to their age. 1) The number of pregnant women was 238,776, and the number of hydatidiform moles was 478. The incidence of hydatidiform mole in pregnant women was 2.00%. 2) The incidence of hydatidiform mole was approximately 1-2% in mothers under 40. The incidence tended to be greater in mothers over 40. The incidence was 27.26% in mothers aged 45 to 49 and 303.03% in mothers over 50 (150 times greater than usual). These results show a clear relationship between the incidence of hydatidiform mole and the mothers age. We believe an increase in abnormal ova is the cause of the increased incidence of hydatidiform mole in older mothers.