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Nonmyeloablative preparative regimens for allogeneic hematopoietic transplantation. Biology and current indications
- Source :
- Oncology (Williston Park, N.Y.). 17(1)
- Publication Year :
- 2003
-
Abstract
- High-dose myeloablative therapy with allogeneic hematopoietic transplantation is an effective treatment for hematologic malignancies, but this approach is associated with a high risk of complications. The use of relatively nontoxic, nonmyeloablative, or reduced-intensity preparative regimens still allows engraftment and the generation of graft-vs-malignancy effects, is potentially curative for susceptible malignancies, and reduces the risk of treatment-related morbidity. Two general strategies along these lines have emerged, based on the use of (1) immunosuppressive chemotherapeutic drugs, usually a purine analog in combination with an alkylating agent, and (2) low-dose total body irradiation, alone or in combination with fludarabine (Fludara).
Details
- ISSN :
- 08909091
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Oncology (Williston Park, N.Y.)
- Accession number :
- edsair.pmid..........c950192832091dceb21fe3f6263b3160