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A prospective study of the association of serum neopterin, beta 2-microglobulin, and hepatitis B surface antigenemia with death in infants and children with HIV-1 disease

Authors :
M J, Di Franco
D, Zaknun
J, Zaknun
E, Vuja
H P, Oswald
P, Mayersbach
D, Hunter
T D, Tosteson
D, Trichopoulos
R, Schmitzberger
Source :
Journal of acquired immune deficiency syndromes. 7(10)
Publication Year :
1994

Abstract

A high percentage of HIV-1-infected infants and children in Romania are coinfected with hepatitis B virus. Little information is available on the impact of concurrent hepatitis B infection on the course of HIV-1 infection. We conducted a prospective cohort study over 1 year in a group of 68 HIV-1-infected infants and children to determine whether hepatitis B surface antigenemia, neopterin, and beta 2-microglobulin (B2M) predicted death. Among the 44 hepatitis B surface antigen-positive (HBsAg+) subjects at enrollment, 13 (30%) died during 1 year of follow-up. In comparison, two of 24 (8%) HBsAg-negative subjects died (RR = 7.7; p = 0.05). Higher initial serum concentrations of neopterin and B2M were negatively associated with survival. After stratifying by baseline clinical evidence of HIV-related disease, survival was negatively associated with HBsAg+ status (p = 0.04) in 33 children in stage P-2, adjusting for age, serum neopterin, and serum B2M levels. The results of this study suggest that serum neopterin is a marker for severity of clinical illness and that HBsAg+ status increases the mortality rate among children with clinical evidence of HIV infection.

Details

ISSN :
08949255
Volume :
7
Issue :
10
Database :
OpenAIRE
Journal :
Journal of acquired immune deficiency syndromes
Accession number :
edsair.pmid..........c86e9ed1a4589736bdd38f57cf1a9831