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Beta-Amyloid (Aβ
- Source :
- Molecules (Basel, Switzerland). 27(8)
- Publication Year :
- 2022
-
Abstract
- Alzheimer's disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief. Recent evidence suggests the γ-aminobutyric acid (GABA) neurotransmitter system undergoes remodeling in AD, disrupting the excitatory/inhibitory (E/I) balance in the brain. Altered expression levels of K-Cl-2 (KCC2) and N-K-Cl-1 (NKCC1), which are cation-chloride cotransporters (CCCs), have been implicated in disrupting GABAergic activity by regulating GABA
Details
- ISSN :
- 14203049
- Volume :
- 27
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.pmid..........c7b4c437d9febbbf9b310f73b6af003b