Evaluation of Tp-E Interval and Tp-E/QT Ratio in Patients with Aortic Stenosis

BACKGROUND: The risk of syncope and sudden cardiac death due to ventricular arrhythmias increased in patients with aortic stenosis (AS). Recently, it was shown that Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratio can be novel indicators for prediction of ventricular arrhythmias and mortality. We aimed to investigate the association between AS and ventricular repolarization using Tp‐e interval and Tp‐e/QT ratio. METHODS: Totally, 105 patients with AS and 60 control subjects were enrolled to this study. The severity of AS was defined by transthoracic echocardiographic examination. Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios were measured from the 12‐lead electrocardiogram. RESULTS: Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios were significantly increased in parallel to the severity of AS (P < 0.001, P = 0.001, and P = 0.001, respectively). Also, it was shown that Tp‐e/QTc ratio had significant positive correlation with mean aortic gradient (r = 0.192, P = 0.049). In multivariate logistic regression analysis, Tp‐e/QTc ratio and left ventricular mass were found to be independent predictors of severe AS (P = 0.03 and P = 0.04, respectively). CONCLUSIONS: Our study showed that Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios were increased in patients with severe AS. Tp‐e/QTc ratio and left ventricular mass were found as independent predictors of severe AS.