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['Tingling feet,' forgetfulness, and progressive personality changes in a 63-year-old patient]

Authors :
T, Karrasch
M, Weil
R, Voltz
C, Schulz
F, Audebert
M, Woenckhaus
F, Hofstädter
U, Bogdahn
J, Schölmerich
A, Schäffler
A, Steinbrecher
Source :
Der Internist. 45(3)
Publication Year :
2004

Abstract

A 63-year-old female was admitted to the hospital with leg and forearm paresthesias. We found progressive ataxia, dementia, and psychosocial deterioration. The clinical symptoms, the neurologic and psychiatric abnormalities together with the inflammatory cerebrospinal fluid alteration and the cerebral magnetic resonance imaging changes suggested a paraneoplastic etiology. It was confirmed by paraneoplastic antineuronal antibodies in the patient's serum and the histological diagnosis of a small cell bronchial carcinoma. The prognosis of patients with paraneoplastic symptoms is the better the earlier a diagnosis is established and antitumor therapy is initiated.

Details

Language :
German
ISSN :
00209554
Volume :
45
Issue :
3
Database :
OpenAIRE
Journal :
Der Internist
Accession number :
edsair.pmid..........c34b03c40abb218dedc59e199a33a9aa