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Action of local anesthetics on basal tone of rat vas deferens and on response to norepinephrine and calcium

Authors :
E, Grana
F, Zonta
G, D'Agostino
G, Dondi
Source :
Archives internationales de pharmacodynamie et de therapie. 247(2)
Publication Year :
1980

Abstract

The actions of three local anesthetics (cocaine, procaine and tetracaine) on basal tone of isolated vas deferens from control and reserpinized rats were studied. The influence of these anesthetics on responses to norepinephrine and calcium was also examined. Cocaine, procaine and tetracaine, in the order, induced phasic and tonic contractions, the latter ones probably due to catecholamine release. The local anesthetics, at the lowest doses, produced an elevation of the maximum response to norepinephrine, as well as a leftward shift of the dose-response curve. The highest doses of local anesthetics inhibited the response to norepinephrine in a non-competitive way, while the response to calcium was competitively inhibited. In this connection, tetracaine proved to be the most active compound. The distinction between destabilizing and stabilizing effects on membrane is pointed out and discussed.

Details

ISSN :
00039780
Volume :
247
Issue :
2
Database :
OpenAIRE
Journal :
Archives internationales de pharmacodynamie et de therapie
Accession number :
edsair.pmid..........c2a813a8a022e7be74997f7f3a11b76f