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CD27
- Source :
- Frontiers in Immunology
- Publication Year :
- 2019
-
Abstract
- Background: Granulomatosis with polyangiitis (GPA) patients are prone to disease relapses. We aimed to determine whether GPA patients at risk for relapse can be identified by differences in B cell subset frequencies. Methods: Eighty-five GPA patients were monitored for a median period of 3.1 years (range: 0.1–6.3). Circulating B cell subset frequencies were analyzed by flow cytometry determining the expression of CD19, CD38, and CD27. B cell subset frequencies at the time of inclusion of future-relapsing (F-R) and non-relapsing (N-R) patients were compared and related to relapse-free survival. Additionally, CD27+CD38hi B cells were assessed in urine and kidney biopsies from active anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV) patients with renal involvement. Results: Within 1.6 years, 30% of patients experienced a relapse. The CD27+CD38hi B cell frequency at the time of inclusion was increased in F-R (median: 2.39%) compared to N-R patients (median: 1.03%; p = 0.0025) and a trend was found compared with the HCs (median: 1.33%; p = 0.08). This increased CD27+CD38hi B cell frequency at inclusion was correlated to decreased relapse-free survival in GPA patients. In addition, 74.7% of patients with an increased CD27+CD38hi B cell frequency (≥2.39%) relapsed during follow-up compared to 19.7% of patients with a CD27+CD38hi B cell frequency of
- Subjects :
- Aged, 80 and over
relapse
Adult
Male
B-Lymphocytes
B cells
granulomatosis with polyangiitis
ANCA
Remission, Spontaneous
Immunology
B-Lymphocyte Subsets
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Middle Aged
Flow Cytometry
Prognosis
ADP-ribosyl Cyclase 1
vasculitis
Tumor Necrosis Factor Receptor Superfamily, Member 7
Antibodies, Antineutrophil Cytoplasmic
Recurrence
Humans
Female
Biomarkers
Aged
Original Research
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in immunology
- Accession number :
- edsair.pmid..........bfeedd92f95eaa7fac9ec1220b2fb4da