[Improving the pathological diagnosis efficacy of fine needle puncture specimens with the changing trend in clinical diagnosis and treatment mode]

The pursuit of minimally invasive biopsy and targeted treatment as well as technical progress have boosted the extensive clinical usages of fine needle puncture cell/tissue acquisition technology in recent years. How to rationally use the limited fine needle puncture materials which are usually minimal and fragmented, while making pathological diagnosis, accomplish the auxiliary tests of immune phenotype, molecular features and other tests required by the clinician, and comprehensively improve the diagnostic benefits of fine needle puncture material is a big challenge facing the pathology community. Up to now, there has been no successful experience that can be learned from abroad. Some suggestions for the further improvement of diagnostic efficacy of fine needle puncture specimens from the aspects of sub-specialty cooperation and comprehensive utilization of the materials are put forward based on the progress trend in pathology and the current situation in China.近年来，对活检微创化、治疗靶向化的追求和技术进步推动了细针穿刺细胞/组织获取技术的广泛临床应用。如何合理使用少而破碎的有限细针穿刺材料，在进行病理诊断的同时，完成临床要求的免疫表型、分子特征等辅助检测，全面提高细针穿刺材料的诊断效益，是病理界面临的挑战。目前，国外尚无成功经验可资借鉴。基于病理发展趋势和我国现状，本文从亚专科合作、材料综合利用等方面对提高细针穿刺标本病理诊断水平提出了一些建议。.