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Brain translocator protein occupancy by ONO-2952 in healthy adults: A Phase 1 PET study using [
- Source :
- Synapse (New York, N.Y.). 71(7)
- Publication Year :
- 2017
-
Abstract
- ONO-2952, a novel antagonist of translocator protein 18 kDa (TSPO), binds with high affinity to TSPO in rat brain and human tumor cell line membrane preparations. This study used the TSPO-specific PET radioligand [
- Subjects :
- Adult
Cyclopropanes
Male
Dose-Response Relationship, Drug
Pyridines
Brain
Middle Aged
Heterocyclic Compounds, 4 or More Rings
Magnetic Resonance Imaging
GABA Antagonists
Young Adult
Receptors, GABA
Positron-Emission Tomography
Acetamides
Linear Models
Humans
Female
Carbon Radioisotopes
Radiopharmaceuticals
Follow-Up Studies
Subjects
Details
- ISSN :
- 10982396
- Volume :
- 71
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Synapse (New York, N.Y.)
- Accession number :
- edsair.pmid..........bbf8dd4c1056309e7bdf4b37ee89a029