[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway]

Study the gene and protein expression of NACHT-PYD-containing protein 3 (NALP3) inflammasome and extracellular regulated protein kinase (ERK), the intervention effects of sodium ferulate (SF) in human lung epithelial cells A549 under oxidative stress, and to investigate the possible mechanism.Human lung epithelial cells A549 culturedCompared with the control group,H₂O₂ not only increased the mRNA and protein expression levels of caspase-1 and NALP3 and the protein expression levels of p-ERK/ERK, but also enhanced the secretion of IL-1β in human lung epithelial cells A549 (SF may reduce the expression of caspase-1, NALP3 and IL-1β by inhibiting ERK, so as to reduce the inflammation caused by oxidative stress.