Phytochemical analysis and inhibitory effects of Calligonum polygonoides on pancreatic α-amylase and β-glucosidase enzymes

OBJECTIVES: To estimate the existence of phyto-chemicals and then to determine the antidiabetic activity against α-amylase and β-glucosidase inhibition in vitro. METHODS: The study was carried out by following standard procedures. RESULTS: Phytochemicals analysis indicated the presence of different phytochemicals. The total phenolic content was 6.055 mg GAE/g and the total flavonoid content was 5.706 mg RU/g in the plant extract. The total saponins, alkaloids, and tannins contents were (0.044%), (2.88%) and (2.862 nm) respectively. α-amylase inhibition activity of Calligonum polygonoides (CP) extract was 70% with IC50 of 610 μg/mL and that of β-gluco-sidase inhibition activity was 65% with IC50 of 640 µg/mL. CONCLUSION: The findings reported for the first time the antidiabetes-promoting effects of an extract of CP in vitro, thus validating their promising anti-diabetes potential.