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Clinical experience with a new recombinant hepatitis-B vaccine in previous non-responders with chronic renal insufficiency
- Source :
- Clinical nephrology. 45(3)
- Publication Year :
- 1996
-
Abstract
- Patients with renal insufficiency have an increased risk of hepatitis B infection and a high probability to develop a chronic course of this disease. After hepatitis B vaccination they are known to show a low rate of seroconversion. In the present study we assessed the efficacy of a new recombinant pre-S1 and pre-S2 containing hepatitis B vaccine in 17 non-responders (anti-HBs titer 0) and 4 low-responders (anti-HBs titeror = 5 IU/ml) with chronic renal insufficiency (16 on chronic hemodialysis therapy and 5 without hemodialysis treatment). Seroconversion rate was 65% after the third and 71% after the fourth vaccination. Only minor side effects were seen. These results encourage to use the new vaccine in a larger number of patients with renal insufficiency.
Details
- ISSN :
- 03010430
- Volume :
- 45
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Clinical nephrology
- Accession number :
- edsair.pmid..........b87d799d6b54eae2ab6cca5e4766a6a2