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[N-of-1 trials: the one and only]
- Source :
- Nederlands tijdschrift voor geneeskunde. 165
- Publication Year :
- 2021
-
Abstract
- Personalized care is a topical issue: the demand for an optimal, individualized treatment instead of uniformity and strict guidelines in increasing. Implementing these ideals in clinical practice often appears to be challenging, as a result of heterogeneity in treatment effects and the influence of patient-specific factors. N-of-1 trials are double-blind, randomized, placebo-controlled trials in an individual patient and can be used to objectively examine the (side)effects of a specific drug, and to compare two or more drugs or variants of the same drug. The results can be used when aiming of deprescribing, but also for evaluating patient-reported intolerances or (in)effectiveness. This article discusses the use and advantages of N-of-1-trials in clinical practice, and addresses its specific concerns and possibilities. The N-of-1-trial is an effective, cost-reducing method to evaluate the effects of a certain drug, which is accessible to nearly every physician and can contribute to safe and effective personalized medicine.
Details
- Language :
- Dutch; Flemish
- ISSN :
- 18768784
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- Nederlands tijdschrift voor geneeskunde
- Accession number :
- edsair.pmid..........b83e5f6c4b89fcff3ac1d8576aab3993