1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D

Authors :: Fabio, Del Bello
Alessandro, Bonifazi
Gianfabio, Giorgioni
Carlo, Cifani
Maria Vittoria, Micioni Di Bonaventura
Riccardo, Petrelli
Alessandro, Piergentili
Stefano, Fontana
Valerio, Mammoli
Hideaki, Yano
Rosanna, Matucci
Giulio, Vistoli
Wilma, Quaglia
Source :: Journal of medicinal chemistry. 61(8)
Publication Year :: 2018
Abstract: In the present article, the M

Subjects :: Male
Guinea Pigs
Receptors, Dopamine D4
Brain
CHO Cells
Quinolones
Ligands
Rats
Molecular Docking Simulation
Mice
Cricetulus
HEK293 Cells
Piperidines
Drug Design
Animals
Dopamine Antagonists
Humans

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