Back to Search Start Over

Liraglutide + PYY

Authors :
Valentin, Metzner
Gloria, Herzog
Tobias, Heckel
Thorsten, Bischler
Julia, Hasinger
Christoph, Otto
Martin, Fassnacht
Andreas, Geier
Florian, Seyfried
Ulrich, Dischinger
Source :
Journal of clinical medicine. 11(3)
Publication Year :
2021

Abstract

Treatment options for NAFLD are still limited. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB), has been shown to improve metabolic and histologic markers of NAFLD. Glucagon-like-peptide-1 (GLP-1) analogues lead to improvements in phase 2 clinical trials. We directly compared the effects of RYGB with a treatment using liraglutide and/or peptide tyrosine tyrosine 3-36 (PYYObese male Wistar rats (high-fat diet (HFD)-induced) were randomized into the following treatment groups: RYGB, sham-operation (sham), liraglutide (0.4 mg/kg/day), PYYRYGB and liraglutide+PYYThe combination therapy of liraglutide+PYY

Details

ISSN :
20770383
Volume :
11
Issue :
3
Database :
OpenAIRE
Journal :
Journal of clinical medicine
Accession number :
edsair.pmid..........b5cb86dbb0ce3ffe6036763b52c2b814