TRPV4 participates in pressure‐induced inhibition of renin secretion by juxtaglomerular cells

Increase in blood pressure in the renal afferent arteriole is known to induce an increase in cytosolic calcium concentration ([Ca2+]i) of juxtaglomerular (JG) cells and to result in a decreased secretion of renin.Mechanical stimulation of As4.1 JG cells induces an increase in [Ca2+]i that is inhibited by HC067047 and RN1734, two inhibitors of TRPV4, or by siRNA‐mediated repression of TRPV4.Inhibition of TRPV4 impairs pressure‐induced decrease in renin secretion.Compared to wild‐type mice, Trpv4 −/− mice present increased resting plasma levels of renin and aldosterone and present a significantly altered pressure–renin relationship.We suggest that TRPV4 channel participates in mechanosensation at the juxtaglomerular apparatus.