Involvement of CD4

To explore the mechanisms involved in the transformation of analgesia produced by low doses of CCL4 (pg/kg) to hyperalgesia when higher doses (ng/kg) are administered to mice.The unilateral hot plate test was used to assess thermal nociception. CD3IL-16 and CCR5 expression were demonstrated in CD4CCL4-evoked hyperalgesia is related to the desensitization of CCR5 in CD4