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Kidney function decline in the elderly: impact of lipoprotein-associated phospholipase A(2)

Authors :
Carmen A, Peralta
Ronit, Katz
Michael, Shlipak
Ruth, Dubin
Ian, DeBoer
Nancy, Jenny
Annette, Fitzpatrick
Carol, Koro
Bryan, Kestenbaum
Joachim, Ix
Mark, Sarnak
Mary, Cushman
Source :
American journal of nephrology. 34(6)
Publication Year :
2011

Abstract

Background: Whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with kidney function decline has not been well studied. Methods: We investigated associations of Lp-PLA2 antigen and activity with kidney function decline and rapid decline over 5.7 years in the Cardiovascular Health Study (n = 4,359). We estimated kidney function by cystatin C (eGFRcys) in repeated measures, and defined rapid decline as ≥3 ml/min/1.73 m2 per year. We stratified by baseline preserved GFR (≥60 ml/min/1.73 m2). Results: Mean age was 72 ± 5 years. Average eGFRcys decline was −1.79 ml/min/1.73 m2 (SD = 2.60) per year. Among persons with preserved GFR, compared to the lowest quartile of Lp-PLA2 antigen, eGFRcys decline was faster among persons in the second, β −0.31 (95% CI −0.52, −0.10), third −0.19 (–0.41, 0.02) and fourth quartiles −0.26 (–0.48, −0.04) after full adjustment. Persons in the highest quartile of Lp-PLA2 antigen had increased odds of rapid decline 1.34 (1.03, 1.75), compared to the lowest. There was no significant association between levels of Lp-PLA2 activity and eGFRcys decline or rapid decline. Associations were not statistically significant among persons with low eGFR (

Details

ISSN :
14219670
Volume :
34
Issue :
6
Database :
OpenAIRE
Journal :
American journal of nephrology
Accession number :
edsair.pmid..........b2e093b5f8ca255035354a7de6a8030c