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COX-2 as possible target for the inhibition of PGE2 production by Rikko-san in activated macrophage
- Source :
- In vivo (Athens, Greece). 22(3)
- Publication Year :
- 2008
-
Abstract
- We have previously reported that Rikko-san (RKS) inhibited the lipopolysaccharide (LPS)-stimulated prostaglandin (PG) E2 in mouse macrophage-like RAW264.7 cells without affecting the expression of cyclooxygenase (COX)-2. Here RKS inhibition of the enzyme activity of both COX-1 and COX-2 proteins was investigated. Western blot analysis showed that RKS did not significantly change the S-nitrosylated COX-2 protein level. On the other hand, RKS inhibited the PG production catalyzed by purified COX-2, more effectively than that catalyzed by purified COX-1. These results suggest that RKS inhibits the PGE2 production by selectively inhibiting the COX-2 activity in activated macrophages.
Details
- ISSN :
- 0258851X
- Volume :
- 22
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- In vivo (Athens, Greece)
- Accession number :
- edsair.pmid..........b14fbeea4cde778972c19cee8e2b6da3