Sleep-promoting activity of lotus (

The sleep-promoting activity ofWe investigated the sleep-promoting activity of LE water extract.Institute of Cancer Research (ICR) mice (An oral administration of 150 mg/kg LE significantly increased sleep duration by 24% compared to the control. Furthermore, LE increased nonrapid eye movement (NREM) sleep by increasing theta and delta powers. In the insomnia model, LE increased sleep time by increasing NREM sleep. Moreover, treatment with picrotoxin and flumazenil decreased the sleep time by 33% and 23%, respectively, indicating an involvement of the GABAThe results suggest that the sleep-promoting activity of LE was via the GABA