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[IGFBP-1 and its protective role in the pathogenesis of microangiopathy in type 1 diabetes mellitus]
- Source :
- Casopis lekaru ceskych. 140(8)
- Publication Year :
- 2001
-
Abstract
- The role of IGF-I/IGFBP's system in the pathogenesis of diabetic vascular complications is widely discussed in the literature. We studied the influence of this system on microvasculature in patients with type 1 diabetes with respect to the effect of IGFBP-1.17 patients with type 1 diabetes were included in the study. We examined IGF-I, IGFBP-1 and IGFBP-3 serum levels, parameters of compensation of diabetes and basic values of lipid metabolism. The function of microvasculature was examined using the laser-Doppler system Periflux. We didn't found any relation between the total IGF-I serum levels, parameters of lipid metabolism or level of diabetes compensation and the degree of impairment of the function of microcirculation. IGFBP-1 serum levels positively correlated with the peak perfusion in thermal hyperaemia (r = 0.39; p0.03). IGFBP-3 serum levels did not affect the function of microcirculation.We can conclude that the activity of IGF-I/IGFBP's system belongs to factors contributing to the development of diabetic microangiopathy in type 1 diabetes. IGFBP-1 as the modulator of IGF-I activity plays probably protective role against the progression of microangiopathy. These results correspond with observations of some other authors.
Details
- Language :
- Czech
- ISSN :
- 00087335
- Volume :
- 140
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Casopis lekaru ceskych
- Accession number :
- edsair.pmid..........b05997b62a4e10c9e7ce613292aeda9b