Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca

Authors :: Federica, Pessina
Alessandra, Gamberucci
Jialin, Chen
Boyin, Liu
Peter, Vangheluwe
Beatrice, Gorelli
Stefania, Lorenzini
Ottavia, Spiga
Alfonso, Trezza
Giampietro, Sgaragli
Simona, Saponara
Source :: Biochemical pharmacology. 155
Publication Year :: 2018
Abstract: 3,5-Di-t-butyl-4-hydroxyanisole (DTBHA) is considered as an activator of the skeletal muscle sarcoplasmic reticulum (SR) Ca

Subjects :: Male
Dose-Response Relationship, Drug
Butylated Hydroxyanisole
Isolated Heart Preparation
Ryanodine Receptor Calcium Release Channel
Myocardial Contraction
Rats
HEK293 Cells
Heart Rate
Animals
Humans
Calcium
Myocytes, Cardiac
Rats, Wistar

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