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An O-to-N intramolecular acyl migration in C₁₉-diterpenoid alkaloids
- Source :
- Journal of Asian natural products research. 14(6)
- Publication Year :
- 2012
-
Abstract
- The O-acyl group at C-1 of two C₁₉-diterpenoid alkaloids 2 and 5 was transferred to the secondary amine nitrogen to form amides 3 and 6 in the basic condition. This kind of O-to-N intramolecular acyl migration could be caused by the near distance between the nucleophilic nitrogen atom and the carbonyl group of the ester at C-1 in the C₁₉-diterpenoid alkaloids, which is consistent with the conformation of rings A and E in the C₁₉-diterpenoid alkaloids.
Details
- ISSN :
- 14772213
- Volume :
- 14
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Asian natural products research
- Accession number :
- edsair.pmid..........aec23030d75e4f81ea8da42376b6d699