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Comparative analysis of immune checkpoint inhibitors and chemotherapy in the treatment of advanced non-small cell lung cancer
- Source :
- Medicine
- Publication Year :
- 2018
- Publisher :
- Wolters Kluwer Health, 2018.
-
Abstract
- Supplemental Digital Content is available in the text<br />Background: Recently, immune checkpoint inhibitors have shown survival advantage over chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC). This meta-analysis was conducted to gather and analyze the available evidence (Evidence level I; Randomized Controlled Trials) comparing efficacy and safety of anti-programmed cell death-1 (PD1)/programmed cell death ligand 1 (PD-L1) therapies and chemotherapy in the treatment of advanced NSCLC. Methods: A search strategy was devised to identify the randomized controlled trials (RCTs) using electronic databases of PubMed, Cochrane Library, and Web of Science. Hazard ratios or odds ratios obtained for overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and treatment related adverse events (TRAEs) were analyzed using fixed effect model or random effects model. Additionally, subgroup analysis was also performed. Results: A total of seven RCTs (n = 3867) were identified and selected for inclusion in this meta-analysis. Anti-PD1/PD-L1 therapies (nivolumab, pembrolizumab, atezolizumab) resulted in better OS (HR 0.72 [95% confidence interval [CI] 0.63, 0.82; P
- Subjects :
- Male
Lung Neoplasms
Programmed Cell Death 1 Receptor
Antibodies, Monoclonal
Antineoplastic Agents
Cell Cycle Checkpoints
Middle Aged
chemotherapy
Antibodies, Monoclonal, Humanized
survival
B7-H1 Antigen
immune checkpoint inhibitors
programmed cell death-1 (PD1)/programmed cell death ligand 1 (PD-L1)
Nivolumab
Treatment Outcome
Carcinoma, Non-Small-Cell Lung
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Humans
Female
Systematic Review and Meta-Analysis
non-small cell lung cancer
Research Article
Randomized Controlled Trials as Topic
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 97
- Issue :
- 33
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.pmid..........ac73546a0c217b57ef39d16041d79293