Cod skin peptide reduces chemotherapy-induced toxicity in gastric cancer patients

The present study was conducted to evaluate the effect of cod skin peptide (CSPE) on chemotherapy-induced toxicity in gastric cancer patients.A cohort of 60 gastric cancer patients for chemotherapy was randomly divided into two groups (n=30 per group), who were orally treated with either supplemental CSPE or placebo apart from chemotherapy. The hematologic and gastrointestinal toxicities experienced by the patients, as well as their Karnofsky Performance Status (KPS) as an index of quality of life was evaluated.Leukocyte counts and haemoglobin levels were significantly reduced in the group treated with peptide (p0.05), while gastrointestinal toxicity was not affected (p0.05). KPS consists of 11 categories of quality of life, and the score denoted in deciles ranges from 100 (asymptomatic, normal function) to 0 (death). The KPS score is used to evaluate a cancer patient's ability to function at work and home, the severity of symptoms, and the patient's need for personal and medical care. Treatment with CSPE significantly improved the quality of life of patients, as indicated by increased KPS scores (p0.05).CSPE can potentially be considered as a food supplement that can be used to improve the quality of life of cancer patients.背景和目的：探讨鱼皮寡肽（CSPE）在降低胃癌患者化疗副反应的作用研 究。方法与研究设计：随机将60 例胃癌化疗患者分为两组（n=30/组），两组 患者除化疗外，分别口服CSPE 或安慰剂，比较两组患者血液学、胃肠道毒性 和生活质量Karnofsky（KPS）评分。结果：安慰剂组白细胞计数和血红蛋白 水平显著低于肽治疗组（p0.05），两组胃肠道毒性无差异（p0.05），KPS 评分主要用于癌症患者工作、家庭生活状况、症状严重程度以及患者对医疗的 需求等11 个类别的生活质量，得分范围从100（无症状，功能正常）到0（死 亡）。CSPE 组KPS 评分显著高于安慰剂组（p0.05），CSPE 明显提高了患 者的生活质量。结论：CSPE 可作为食品补充剂改善癌症患者的生活质量。.