[Adrenal cortical tumors. Prognostic evaluation of a series of 12 cases using anti-PCNA antibodies]

Adrenocortical tumors malignancy may be difficult to assess by morphological data. Twelve cases of such tumors were reviewed and classified benign (group I) or malignant (group II) according to follow yp. Using a peroxidase antiperoxidase method, nuclear affinity for anti-PCNA antibody was studied. The percentage of positive nuclei is significantly different in both groups: the mean value is 1.025% in benign tumors (range from 0.40 to 3.02%) and 16.765% (range from 5.62 to 31.40%) in malignant tumors (p0.01 according to Mann and Whitney U test). Although our study group is rather small, it suggests that analysis of nuclear affinity for PCNA could be helpful in assessment of adrenocortical tumors malignancy.