DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A

Authors :: Rangel L, Silva
Gabriela T, Silveira
Carlos W, Wanderlei
Nerry T, Cecilio
Alexandre G M, Maganin
Marcelo, Franchin
Lucas M M, Marques
Norberto P, Lopes
José A, Crippa
Francisco S, Guimarães
José C F, Alves-Filho
Fernando Q, Cunha
Thiago M, Cunha
Source :: Toxicology and applied pharmacology. 368
Publication Year :: 2018
Abstract: Cannabidiol (CBD) is a natural compound with psychoactive therapeutic properties well described. Conversely, the immunological effects of CBD are still poorly explored. In this study, the potential anti-inflammatory effects and underlying mechanisms of CBD and its analog Dimethyl-Heptyl-Cannabidiol (DMH-CBD) were investigated using RAW 264.7 macrophages. CBD and DMH-CBD suppressed LPS-induced TNF production and NF-kB activity in a concentration-dependent manner. Both compounds reduced the NF-kB activity in a μM concentration range: CBD (IC

Subjects :: Secretory Pathway
Adenosine A2 Receptor Agonists
Dose-Response Relationship, Drug
Receptor, Adenosine A2A
Cell Survival
THP-1 Cells
Tumor Necrosis Factor-alpha
Macrophages
NF-kappa B
p38 Mitogen-Activated Protein Kinases
Inhibitory Concentration 50
Mice
RAW 264.7 Cells
Animals
Cannabidiol
Humans
Phosphorylation
Signal Transduction

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