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Cyclooxygenase-2 expression in human soft-tissue sarcomas is related to epithelial differentation
- Source :
- Anticancer research. 25(4)
- Publication Year :
- 2005
-
Abstract
- Cyclooxygenase-2 (Cox-2) is expressed by several types of epithelial malignancies, i.e., carcinomas, and inhibition of Cox-2 may have a therapeutic role in chemoprevention and treatment of cancer. The role of Cox-2 in non-epithelial malignancies, however, is unclear.We investigated, by immuno- histochemistry, the expression of Cox-2 in 103 human soft-tissue sarcomas.All 10 biphasic synovial sarcomas were positive for Cox-2, but positivity was observable only in the epithelial component of these tumours. Excluding sarcomas with epithelial differentation, uniform staining of the tumour was observed in only 2 samples. In addition, positivity for Cox-2 appeared in tumour cells in only 18 samples around necrotic areas.In human soft-tissue sarcomas, Cox-2 expression seems to be associated with epithelial differentation and, in some types of sarcomas, to be expressed in otherwise negative tumours at sites of necrosis.
Details
- ISSN :
- 02507005
- Volume :
- 25
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.pmid..........a9e6f68c12b60bc3f371e3d407369a6c