Back to Search
Start Over
[Determination of proliferation in breast cancer by immunohistochemical detection of Ki-67]
- Source :
- Der Pathologe. 35(1)
- Publication Year :
- 2014
-
Abstract
- Gene expression profiling has demonstrated the prognostic relevance of genes associated with proliferation in breast cancer. The immunohistochemical marker Ki-67 enables routine assessment of proliferation activity in pathology. In a number of retrospective but only few prospective studies the prognostic relevance of Ki-67 in breast cancer could be shown. Although there is no standardized approach with regard to which area of a histological section and how many cells should be counted in a quantitative or semiquantitative fashion as well as to the threshold, Ki-67 is broadly applied in breast pathology. This can be explained by the good reproducibility of the degree of proliferation assessed by Ki-67, at least in the low and high ranges, the possibility to substantiate grading and better practicability in core biopsies in comparison to mitotic counting. In neoadjuvant therapy of hormone receptor positive breast cancer, Ki-67 can probably predict the efficacy of pure hormone receptor blockade without chemotherapy.
- Subjects :
- Neoplasms, Hormone-Dependent
Receptor, ErbB-2
Gene Expression Profiling
Biopsy, Needle
Breast Neoplasms
Prognosis
Combined Modality Therapy
Neoadjuvant Therapy
Carcinoma, Ductal
Immunoenzyme Techniques
Ki-67 Antigen
Receptors, Estrogen
Biomarkers, Tumor
Humans
Female
Breast
Neoplasm Grading
Receptors, Progesterone
Cell Proliferation
Subjects
Details
- Language :
- German
- ISSN :
- 14321963
- Volume :
- 35
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Der Pathologe
- Accession number :
- edsair.pmid..........a6e7aa85a92539c7d0fc0307a69a76e9