[Studies of genetic polymorphism of CYP450 2E1 among the Tibetan populations in Qinghai Province and its effect on drinking behavior]

In order to explore the effect of genetic polymorphism of CYP450 2El among the Tibetan population in Qinghai and its relationship to drinking behavior.By the self-reported questionnaires of 325 Tibetan male who contain 193 drinkers and 132 non-drinkers, we analyzed the relationship between drinking behavior and the genetic polymorphism of CYP450 2El by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. So does the 266 Han nationalism.Single variable analysis showed the drinking prevalence was related to occupation, educational status, economic income, marital status and smoking (P0.05). There were no statistical significant differences of genotypes and alleles between male Tibetan and Han population (P0.05). The three genotypes (cl/cl, cl/c2, c2/c2) and the two alleles (cl, c2) of CYP450 2El had statistical significant differences (P0.05) between drinkers and non-drinkers in Tibetan population, and the drinkers had higher frequencies of cl/c2 genotype and c2 allele than that of the opposite group. Compared with safe drinkers, the frequency of c2 allele in the group of dangerous was higher. The related degree of drinking behavior and amount with c2 allele were 0.17 and 0.20. The multivariate statistical analysis showed that CYP450 2E1, incomes and smoking were independent.CYP450 2E1 is the mostly influence factor to drinking behavior in male Tibetan population.