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Secreted amyloid-β precursor protein functions as a GABA
- Source :
- Science (New York, N.Y.). 363(6423)
- Publication Year :
- 2017
-
Abstract
- Amyloid-β precursor protein (APP) is central to the pathogenesis of Alzheimer's disease, yet its physiological function remains unresolved. Accumulating evidence suggests that APP has a synaptic function mediated by an unidentified receptor for secreted APP (sAPP). Here we show that the sAPP extension domain directly bound the sushi 1 domain specific to the γ-aminobutyric acid type B receptor subunit 1a (GABA
- Subjects :
- Male
Mice, Knockout
Neurons
Proteomics
Mice, Inbred BALB C
Neuronal Plasticity
Membrane Proteins
Receptors, GABA-A
Hippocampus
Synaptic Transmission
Mice, Inbred C57BL
Amyloid beta-Protein Precursor
Mice
HEK293 Cells
Protein Domains
Synapses
Animals
Humans
Amino Acid Sequence
Synaptic Vesicles
Peptides
Cells, Cultured
Protein Binding
Subjects
Details
- ISSN :
- 10959203
- Volume :
- 363
- Issue :
- 6423
- Database :
- OpenAIRE
- Journal :
- Science (New York, N.Y.)
- Accession number :
- edsair.pmid..........a62010093beb8c535651e6903a9c70a7