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Two sides of the coin: Cytoskeletal regulation of immune synapses in cancer and primary immune deficiencies

Authors :
Mezida B, Saeed
Julien, Record
Lisa S, Westerberg
Source :
International review of cell and molecular biology. 356
Publication Year :
2020

Abstract

Actin cytoskeleton remodeling facilitates and fine-tunes diverse cellular processes. Cells have evolved to use the same building blocks of actin monomers to form filaments through the sequential and synchronous use of actin filament regulators. This is best illustrated in immune cells which rely on a highly dynamic cytoskeleton to patrol the body and recognize and respond to cancer cells. Here, we highlight key actin regulators that are differentially expressed in immune cells and the immune cell biology learned from disease-causing mutations in these actin regulators. Moreover, we discuss two important aspects of the actin cytoskeleton in controlling cancer: the engagement in multiple phases of immune cell activation and effector function as well as the role in cellular transformation. We conclude by reflecting on how these two aspects can be balanced in developing novel chemotherapies.

Details

ISSN :
19376448
Volume :
356
Database :
OpenAIRE
Journal :
International review of cell and molecular biology
Accession number :
edsair.pmid..........a556c585d19fb7ab05d147f6454e0a1b