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A Case-Control Study of ABCB1, ABCB6, and ABCG1 Polymorphisms and Schizophrenia in a Han Chinese Population
- Source :
- Neuropsychobiology. 78(3)
- Publication Year :
- 2018
-
Abstract
- Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Mutations in the members of ABC transporters have been associated with psychiatric illnesses.In this study, we investigated whether 9 SNPs in ABCB1 (rs6946119, rs28401781, rs4148739, and rs3747802), ABCB6 (rs1109866, rs1109867, rs3731885, and rs3755047), and ABCG1 (rs182694) contribute to the risk of SCZ in a Han Chinese population.We conducted a case-control study in a Han Chinese population, involving 1,034 SCZ patients and 1,034 unrelated healthy controls to genotype 9 SNPs.The analysis demonstrated that rs182694 of ABCG1 was significantly different between SCZ patients and controls as to allele (rs182694: p = 0.0070, χ2 = 7.27) and genotype frequencies (rs182694: p = 0.0013, χ2 = 13.35).Our findings support an association between ABCG1 polymorphism and SCZ in a Han Chinese population.
- Subjects :
- Adult
Aged, 80 and over
Male
China
ATP Binding Cassette Transporter, Subfamily B
Adolescent
Genotype
Polymorphism, Single Nucleotide
Young Adult
Asian People
Case-Control Studies
Schizophrenia
Humans
ATP-Binding Cassette Transporters
Female
Child
ATP Binding Cassette Transporter, Subfamily G, Member 1
Aged
Subjects
Details
- ISSN :
- 14230224
- Volume :
- 78
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Neuropsychobiology
- Accession number :
- edsair.pmid..........a438d131e3fa3d5268c06b2d3d78ee73