Back to Search
Start Over
Immune monitoring with a lymphocyte adenosine triphosphate assay in kidney transplant recipients treated with a calcineurin inhibitor
- Source :
- Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 12(3)
- Publication Year :
- 2014
-
Abstract
- The adenosine triphosphate assay using peripheral lymphocytes may be useful to evaluate the risks of acute rejection and infection in kidney transplant patients. We used the adenosine triphosphate assay to evaluate differences between recipients who were treated with cyclosporine- or tacrolimus-based immunosuppressive therapy.Adenosine triphosphate levels were measured in peripheral CD4+ cells before and after transplant and were correlated with clinical outcomes in 45 kidney transplant recipients. These recipients received immunosuppressive therapy with either cyclosporine (23 patients) or tacrolimus (22 patients).Adenosine triphosphate levels were significantly lower in the cyclosporine- than tacrolimus-based therapy groups from 2 to 6 weeks after transplant. Adenosine triphosphate levels were similar between these groups before and 1 week after transplant. The frequency of cytomegalovirus infection was greater in the recipients who received cyclosporine (17 patients [74%]) than tacrolimus (6 patients [27%]; P ≦ .003). The frequency of acute rejection episodes was similar between the cyclosporine and tacrolimus groups.These observations suggest that cyclosporine-based immunosuppressive therapy causes excessive immunosuppression compared with tacrolimus-based therapy, evidenced by the lymphocyte adenosine triphosphate levels. The adenosine triphosphate assay using peripheral CD4+ cells may be a useful method for predicting the occurrence of cytomegalovirus infections in kidney transplant recipients.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Graft Rejection
Male
Time Factors
Calcineurin Inhibitors
Middle Aged
Kidney Transplantation
Tacrolimus
Young Adult
Adenosine Triphosphate
Treatment Outcome
Monitoring, Immunologic
Predictive Value of Tests
Cytomegalovirus Infections
Cyclosporine
Humans
Female
Drug Monitoring
Biomarkers
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 21468427
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
- Accession number :
- edsair.pmid..........a3ce057068e97f0ff11acb4fff4facc1