[Clinical and pathogenetic aspects of aspirin intolerance]

Aspirin intolerance has become increasingly important in clinical dermatology during the past decade, especially as a diagnostic aid in chronic urticaria. It is recommended, to distinguish clinically between the intolerance syndrome and an intolerance provocation (of preexistent asthma or urticaria). Pathogenetically, various antibody-independent mechanisms are discussed of which most authors favour a defective regulation of arachidonic acid metabolism.