[Analysis on Death Cases in Children with Acute Lymphoblastic Leukemia Treated with the CCLG-ALL 2008 Protocol]

To retrospective analyze the reason of death in children with acute lymphoblastic leukemia (ALL) treated with CCLG-ALL 2008 protocol, and the experience was summarized in order to reduce the mortality.916 children diagnosed as ALL and accepted CCLG-ALL 2008 protocol from April 2008 to April 2015 in our hospital were enrolled, the dead cases in them were analyzed retrospectively.169 children died, including 111 (65.7%) males and 58 (34.3%) females. Recurrence was the main reason of death. 150 (88.7%) children died due to recurrence, among them, 86 (57.3%) cases gave up directly. The second reason of death was infection. The main clinical sites of infection were concentrated in respiratory system and digestive system. Bacterial infection was most common (Gram-negative was common).Enough finance and improving family compliance can decrease the mortality in children with ALL. Early rational use of antibiotics can reduce infection-related mortality in children with ALL.CCLG-ALL2008方案治疗儿童急性淋巴细胞白血病死亡病例分析.回顾性分析应用CCLG-ALL2008方案治疗儿童急性淋巴细胞白血病（ALL）患者的死亡原因，总结经验，以期降低患儿死亡率.2008年4月至2015年4月在本院诊断并接受CCLG-ALL2008方案治疗的儿童ALL患者共计916例，选取其中死亡的病例进行回顾性分析.死亡患者共169例，男性111例（65.7%），女性58例（34.3%）。复发为主要的死亡原因，由复发导致死亡的患者有150例（88.7%），其中86例（57.3%）复发后家属直接放弃治疗。第二死亡原因为感染，感染部位主要集中在呼吸系统和消化系统，以细菌感染为主（多见于革兰氏阴性杆菌）.加强经济支持、提高家属依从性可以降低儿童ALL的死亡率，早期合理地使用抗生素可以降低儿童ALL的感染相关死亡率.