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Cholesterol synthesis by human fibroblasts in the presence of LDL and anti-LDL IgA
- Source :
- Biomedicine / [publiee pour l'A.A.I.C.I.G.]. 31(3)
- Publication Year :
- 1979
-
Abstract
- LDL interact with fibroblasts through specific membrane sites. This reaction is the first step of a mechanism which leads to the regulation of intracellular cholesterol synthesis. When LDL form a complex with an IgA from a myeloma serum with mixed hyperlipidemia and xanthomatosis, they no longer function as a regulator, and the result is excess production of free intracellular cholesterol. No excess cholesterol production is observed when myeloma IgA is replaced by control IgG and IgA.
Details
- ISSN :
- 03000893
- Volume :
- 31
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biomedicine / [publiee pour l'A.A.I.C.I.G.]
- Accession number :
- edsair.pmid..........9e16c824d9f06109b8123f7da1296c31