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[Screening of serum protein biomarkers by surface-enhanced laser desorption and ionization with time-of-flight detection mass spectrometry in patients with mycosis fungoides]
- Source :
- Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 31(1)
- Publication Year :
- 2009
-
Abstract
- To screen serum biomarkers in patients with mycosis fungoides (MF) using surface-enhanced laser desorption and ionization with time-of-flight detection mass spectrometry (SELDI-TOF-MS) technique.Serum was analyzed from 14 patients with MF and 17 controls using CM10 Protein-chip to capture serum proteins, followed by Biomarker Wizard software analysis.In all specimens, about 131 protein peaks could be detected when the relative molecular weight ranged from 0 to 50 000. When comparing the protein fingerprint between these two groups, 14 differentially expressed protein peaks were found. By searching SWISS-PRO database, we found 7 670Da peaks accord with C-C motif chemokine 22.SELDI-TOF-MS technique can be used for screening serum protein biomarkers in patients with MF.
Details
- ISSN :
- 1000503X
- Volume :
- 31
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
- Accession number :
- edsair.pmid..........9b347c0dbfc9ea228d9cb60d5efe849b