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Specific inhibition of RHo(D) antibody by sialic acids

Authors :
M C, DODD
N J, BIGLEY
V B, GEYER
Source :
Science (New York, N.Y.). 132(3437)
Publication Year :
1960

Abstract

Agglutination of Rh(O)(D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. A brain ganglioside containing neuraminic acid and a Pseudomonas polysaccharide were even more inhibitory. Inhibition was specific for anti-D sera.

Details

ISSN :
00368075
Volume :
132
Issue :
3437
Database :
OpenAIRE
Journal :
Science (New York, N.Y.)
Accession number :
edsair.pmid..........9b0e32aaa2f7c68775f0bd8bd2dbf520